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Title | PACKER LAB - |
Description | All-optical interrogation of neural circuits during PACKER LAB Research Publications People Contact All-optical interrogation of neural circuits during behaviour Packer et al Nature Neuroscience 2013 Pac |
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WebSite | packerlab.org |
Host IP | 199.34.228.78 |
Location | United States |
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US$1,799,853
Last updated: 2023-05-19 17:40:54
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PACKER LAB Research Publications People Contact All-optical interrogation of neural circuits during behaviour Packer et al Nature Neuroscience 2013 Packer et al Nature Methods 2015 Neural circuits display complex spatiotemporal patterns of activity on the millisecond timescale. Understanding how these activity patterns drive behaviour is a fundamental problem in neuroscience. To address this challenge, we have recently introduced a novel approach that combines simultaneous two-photon calcium imaging and two-photon targeted optogenetic photostimulation with the use of a spatial light modulator (SLM) to provide ’all-optical’ readout and manipulation of the same neurons in vivo. We probe the neural code in mouse barrel cortex during sensory-guided behavioural tasks by using this approach to uncover the underlying mechanisms of decoding and encoding of information by ensembles of neurons. We train mice to make perceptual decisions based on quantitative control of cortical activity, as |
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